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Adrafinil's Effects and Benefits

Adrafinil is a synthetic nootropic used to enhance cognitive function including focus, memory, and problem solving abilities. It acts as a pro-drug for Modafinil. A pro-drug means that after you consume Adrafinil, your liver converts it into Modafinil inside your body. Even though Modafinil can be consumed directly, and is available over the counter in many countries, it is a prescription drug in the United States. Adrafinil, however, does not require a prescription in the United States. It is legal to possess and carries similar effects/benefits when compared to Modafinil.

Adrafinil was originally developed in France by Louis Lafon Laboratories. Their goal was to design a novel pharmaceutical which carries the same positive effects of a stimulant while at the same time lacking many of the undesirable side effects. The result was Adrafinil, a nootropic which acts as a very mild stimulant carrying the benefits described below:

Adrafinil's Benefits

  • Improves focus and vigilance. [1][3][7][8][10][12][16][17][18]
  • Improves cognition and problem solving abilities. [1][3][16][17]
  • Improves motivation [3][18]
  • Improves reaction-time [18]
  • Neuroprotective [3][5][15]
  • Treats narcolepsy, sleep-work shift disorder, and other vigilance related conditions. [3][7][8][11][12][18]
  • Improves memory and recall. [3][16][17]
  • May treat mild depression, most compelling evidence seen in clinical trials on elderly patients. [3] Has been shown to be effective at augmenting the benefits of SSRI therapy for major depressive disorder (MDD) by alleviating the persistent fatigue and sleepiness commonly associated with MDD. [14]
  • Improves motor function in people with minor cognitive impairment. [3]
  • Improves symptoms associated with ADD and ADHD[13][16][17]
  • May be beneficial in treating cocaine and methamphetamine dependence. [20]

Will Adrafinil Help Me?

Adrafinil is one of the most potent nootropics available in regards to enhancing energy, attention, and focus. In order to get something more powerful, such as Adderall, you would need a prescription. Additionally, many of the more powerful prescription drugs carry more intense side effects and a larger potential for addiction/dependence.

If you are looking for something which is legal, and will give you the edge you need to work for long periods of time, whether for school or at work, Adrafinil will help. It is becoming very popular among not just students trying to pull all-nighters, but also among workers who need to stay focused and motivated for long periods of time.

Adrafinil as a Study Aid

Adrafinil is an excellent nootropic for use as a study aid. The biggest problems students face in regards to studying are:

  1. Feeling motivated enough to begin a study session.
  2. Being able to stay focused on the material without frequently checking their phones or social media.
  3. Having enough energy to study for long periods of time (especially when trying to cram before a large test)
  4. Understanding and remembering everything being studied.

Adrafinil helps solve all of these problems. Approximately 30 minutes after consumption, you will begin to feel more energetic and awake. Many times people also feel more motivated and experience a slight sense of increase in well-being. This boost is usually more than enough to get any student to crack open a text book and get to work.

The increased level of attention and focus keeps one’s mind on the work at hand. You will find you won’t care quite as much about checking your social media or phone. The task at hand will be more important and your mind will wander less.

For those trying to pull and all-nighter, you won’t get as tired as quickly. A person’s ability to understand and remember information is largely dependent on how focused they are on what they are trying to learn. This is why it is much easier to recall the fine details of an enthralling movie compared to a boring lecture. Staying focused on the material you are trying to learn will allow you to recall more information when taking a test.

Adrafinil for Working Long Hours

Adrafinil isn’t only being used by students, it is also used by many individuals to make the work day more bearable. For those of us working in an office, looking at excel spreadsheets for over 8 hours a day, it can be hard to stay focused. Some jobs require even more than 8 hour days. It is no surprise that burn-out is so prevalent in many of the more intense office jobs.

The majority of the world uses coffee in an attempt to get through these brutal work days. But many people find coffee to be inadequate for the following reasons:

  1. You build a tolerance to coffee very quickly. At first, coffee provides you with an extraordinary boost to energy and focus. Anyone who can remember the first time they took coffee knows this. But after a couple weeks of regular use, coffee becomes something you take just to return to a baseline level of energy. Instead of coffee helping you function beyond 100% it is taken just to keep you from functioning at 50%.
  2. Coffee doesn’t last very long, and when it wears off you “crash”. There is a definitive peak in regards to coffee’s effects, and when it wears off you feel more drained than before you drank it.
  3. Many people get “jitters” or feel anxious after drinking coffee. As one’s tolerance to coffee builds, they drink more and more to get the same effect. For many people, this leads to feeling anxious and jittery despite not feeling energized or focused.

Adrafinil doesn’t carry many of these same problems:

  1. You do not build a tolerance to Adrafinil nearly as quickly. A similar dose generally provides someone with the same feeling day after day. Furthermore, long term adrafinil use has been shown to increase certain liver enzymes. For this reason, it is recommendedto use Adrafinil for no more than three weeks at a time and take an extended break before resuming use. This will also eliminate any tolerance.
  2. Adrafinil does not carry a “crash” or “peak”. The increased energy and focus adrafinil provides is a very “even” feeling that lasts upwards of 8-10 hours. You feel just as energized after 6 hours as you do after 2 hours.
  3. Most people do not experience anxiety or jitters like they would after downing a large coffee. The result is energy that feels cleaner and is more effective.

The bottom line is this, Adrafinil gives you an edge throughout the entire work day which makes mental work less demanding and exhausting. The edge it provides is far superior to coffee’s, despite coffee’s popularity.

What Research Supports Adrafinil's Benefits?

Many of the studies are conducted directly on Modafinil’s effects. Modafinil itself is a prescription drug, and for this reason it is being more heavily studied. But Adrafinil is the pro-drug to Modafinil. Adrafinil has the same effects, benefits, and mechanism of action as Modafinil. All of the studies conducted on the benefits of Modafinil similarly apply to Adrafinil.

Adrafinil and Focus

Many scientific studies have shown Adrafinil is able to improve focus and concentration. For example, the following study conducted on young, healthy adult male volunteers studied their ability to perform attention and memory tasks after taking a single oral dose of either a placebo, 100mg, or 200mg of Modafinil.

After taking the dose, the participants performed tests designed to measure visual pattern recognition, memory, spatial planning and reaction time.

The results showed Modafinil significantly enhanced performance on all of the tests described above. Additionally, the researchers asked the subjects how they felt after taking the Modafinil. Those whom took either 100mg or 200mg reported feeling more alert, attentive, and energetic. Interestingly, the effects were not dose dependent. This means those taking either 100mg or 200mg performed similarly on the tasks assigned to them. [17]

This directly supports Adrafinil’s ability to help a student study for longer periods of time and remember more of what they are studying. It also supports Adrafinil’s benefit of helping a worker stay glued to their computer for the 8 hour work day.

Adrafinil and Cognition, Problem Solving, and Motivation

Another study showed Adrafinil enhanced task enjoyment and performance on cognitive tests of planning and working memory.

A double-blind placebo controlled study evaluated the effect of either 200mg of Modafinil or a placebo. The study used healthy, non-sleep deprived volunteers. These volunteers performed tasks used to measure creative thinking, motivation/task enjoyment, and planning/decision making.

The group given 200mg of Modafinil performed better on spatial working memory, planning and decision making tests at the more difficult levels. Additionally, the subjects given the Modafinil reported significantly higher levels of enjoyment while performing the tasks. The effects of Modafinil on creativity were inconsistent, and the results showed no positive or negative effect.

It is important to note this study used non-sleep deprived volunteers. Many critics of Modafinil and Adrafinil state the effects on memory and attention are derived simply from the nootropic’s ability to promote wakefulness and increase levels of energy. This study contradicts this claim. It shows that individuals whom are not already impaired by lack of sleep can benefit remarkably from Modafinil. [21]

IMPORTANT: Always consult a doctor being using Adrafinil or any other nootropic.

Do not consume more than 600mg of adrafinil in a single day. If adrafinil is taken every day for three weeks, do not take adrafinil the following week. Do not use Adrafinil if pregnant, nursing, or taking any other medications. If you experience any adverse effects while taking Adrafinil, discontinue use and consult your doctor immediately. Do not operate any machinery until you know how Adrafinil will affect you.

Please keep in mind Adrafinil is one of the most potent nootropics you can obtain without a prescription. Use it responsibly, do not abuse or use too excess.

Cited Sources

  1. Adrafinil: Effects on Behavior and Cognition in Aged Canines
  2. World Anti-Doping Agency Banned Substances List
  3. Adrafinil: A Novel Vigilance Promoting Agent
  4. A possible alpha-adrenergic mechanism for drug (CRL 40028)-induced hyperactivity.
  5. Effects of drugs affecting the noradrenergic system on convuslisons in the quaking mouse.
  6. A new approach to the light/dark test procedure in mice.
  7. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.
  8. Successful treatment of idopathic hypersomnia and narcolepsy with modafinil.
  9. Modfinil-induced orofacial dyskinesia in an elderly patient with refactory bipolar depression.
  10. Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs.
  11. A systematic review of Modafinil: Potential Clinical Uses and Mechanisms of Action.
  12. Modafinil for Excessive Sleepiness Associated with Chronic Shift Work Sleep Disorder
  13. Modfinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescents.
  14. Modfinil augmentation of SSRI therapy in MDD partial responders with persistent fatigue and sleepiness
  15. Neuroprotective effects of modafinil in a marmoset Parkinson model.
  16. Modfinil improves cognition and attentional set shifting in patients with chronic schizophrenia.
  17. Cognitive enhancing effects of modafinil in healthy volunteers.
  18. Effects of modafinil on cognitive and meta-cognitive performance.
  19. Modifinal decreases food intake in humans subjected to simulated shift work.
  20. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.
  21. Effects of Modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.

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